The Mokolodi Wildlife Foundation was formed in 1991 to promote wildlife conservation and environmental education for the children of Botswana. The foundation lead to the establishment of the Mokolodi Nature Reserve in 1994.

Today it is run by a Board which devote their time and efforts to making decisions for Mokolodi Nature Reserve and to ensure the goals are carried out effectively. The board meets on a quarterly basis but consists of a smaller Executive Committee which meets more frequently.

The current chairperson is Dr. Ian S. Kirby and the vice chairperson is Mr. Ramachandran Ottaphatu.